Cyclopropanemethyl esters

ABSTRACT

Organic esters and thioesters characterized by the presence of a cyclopropane moiety, synthesis thereof, and compositions thereof for the control of mites and ticks.

United States Patent [191 Henrick et al.

[ CYCLOPROPANEMETHYL ESTERS [75] Inventors: Clive A. Henrick; Gerardus B. Staal,

both of Palo Alto, Calif.

[73] Assignee: Zoecon Corporation, Palo Alto,

Calif.

[22] Filed: Nov. 5, 1973 [21] Appl. No.: 412,806

Related US. Application Data [63] Continuation-in-part of Ser. No. 350,708, April 13, 1973, which is a continuation-in-part of Ser. No. 263,902, June 19, I972, abandoned, which is a continuation-in-part of Ser. No. 255,368, May 22, I972, abandoned.

[52] US. Cl 260/469; 260/455 R; 260/468 R; 260/468 l-l; 260/468 J; 260/468 K; 260/473 R; 260/476 R; 260/468 L; 424/301; 424/305;

424/308 [51] Int. Cl. C07C 69/76 [58] Field of Search 260/476 R, 469

[ Dec. 23, 1975 OTHER PUBLICATIONS Chemical Abstracts, Vol. 72, 121 138W (1970).

Primary Examiner-Lorraine A. Weinberger Assistant Examiner-Jane S. Myers Attorney, Agent, or FirmDonald W. Erickson [57] ABSTRACT Organic esters and thioesters characterized by the presence of a cyclopropane moiety, synthesis thereof, and compositions thereof for the control of mites and ticks.

9 Claims, No Drawings CYCLOPROPANEMETHYL ESTERS This is a continuation-impart of Ser. No. 350,708, filed Apr. 13, 1973, which is a continuation-in-part of Ser. No. 263,902, filed June 19, 1972 now abandoned, which is a continuation-in-part of Ser. No. 255,368, filed May 22, 1972 now abandoned. This invention relates to novel compounds, synthesis thereof, compositions thereof, and the control of mites and ticks.

The compounds of the present invention are effective for the control of mites and especially spider mites. Spider mites are plant feeders and cause serious damage to orchard trees, field crops, greenhouse plants and other vegetation. They feed on the foliage of fruit of plants and trees and attack a variety of plants and trees due to their wide distribution. Spider mites of the family Tetranychidae, such as Tetranychus urticae, Tetranychus canadensis, Tetranychus cinnabarinus, Tetranychus pacificus, Bryobia praetiosa, Oligonychus pratensis, Oligonychus ilicis, Panonychus citri, Panonychus ulmi, and similar related species, are of particular biological interest and economic importance. Other mites are those of the family Tarsonemidae, such as Steneotamonemus pallidus.

Compounds of the present invention of the following formulas A and B are effective control agents for spider mites.

X is oxygen or sulfur;

H is phenyl, naphthyl or cycloalkyl, each optionally substituted by one or more halogen, alkyl, alkoxy, aralkoxy, aryl or aryloxy groups;

n is 1 or 2; and

n is O or a positive integer from 1 to 10.

Hereinafter, each of R, X, n and n is as defined above unless otherwise specified.

Preferred compounds within this class are those wherein the R group is phenyl or naphthyl and one of the substituents on the R group is in the para-position relative to the acid group attached to the ring. Preferred substituents are alkyl of one to ten carbon atoms, alkoxy of one to ten carbon atoms, phenyl, phenylalkyl of seven to ten carbon atoms, phenylalkoxy of seven to ten carbon atoms, chlorine or bromine.

Especially preferred are those compounds where n is one or n is 0, l or 2, and the R group is phenyl and is substituted in the para-position by methyl, octyl, phenyl, benzyl, methoxy, phenoxy, octyloxy, benzyloxy, or chloro.

The compounds of formula A or B are applied to the mite at any stage, namely during the egg, larvae, nymphal or adult stages in view of their effect in causing inhibition of egg hatching abnormal development leading to death, inability to pass from one stage to the next, or inability to reproduce. Some of the compounds also exhibit a residual ovicidal effect. A compound of formula A or B or mixtures thereof, can be applied at dosage levels of the order of 0.001 to 1 percent. Suitable carrier substances include liquid or solid inert carriers, such as water, acetone, xylene, mineral or vegetable oils, talc, vermiculite, and silica. Treatment of mites in accordance with the present invention can be accomplished by spraying, dusting, or otherwise contacting the mites and/or their eggs or larvae directly or indirectly. Generally, a concentration of less than 25 percent of active compounds is employed, although a higher concentration of the active compound can be used depending on the type of application apparatus. The formulations can include emulsifying agents and wetting agents to assist in the application and effectiveness of the ingredient.

The esters and thioesters of this invention are prepared by conventional esterification methods, for example by reacting an acid halide of the formula R(CH=CH),.CHal

R(CH C-Ha1 with cyclopropanemethyl alcohol or I cyclopropanemethyl mercaptan with or without added pyridine to obtain the corresponding ester or thioester. The reaction may be carried out neat or in an organic solvent inert to the reaction, such as a hydrocarbon or ether solvent. Usually an excess of the alcohol or mercaptan is employed and the reaction proceeds at room temperature satisfactoriy, although higher or lower temperatures may be used.

Alternatively, the esters may be prepared by transesterification of a corresponding alkyl ester with the lithium salt of cyclopropanemethyl alcohol, or esterification with cyclopropanemethyl alcohol and acid catalyst, in an inert solvent.

Cyclopropanemethyl alcohol can be prepared as described by Sarel and Newman, J. Am. Chem. Soc. 78, 5416 (1956); Sneen et al, ibid, 83, 4842 (1961); Siegel and Bergstron, ibid 72, 3815 (1950) and 74, (1952); US. Pat. Nos. 2,294,084 and 3,074,984; and references cited therein.

The term alkyl, as used herein, refers to a straight or branched chain saturated aliphatic hydrocarbon group of one to fifteen carbon atoms, e.g., methyl, ethyl, propyl, i-propyl, n-butyl, s-butyl, t-butyl, pentyl, hexyl, heptyl, n-octyl, 2-methyloctyl, nonyl, decyl, undecyl, 2-methylundecyl, 6-methylundecyl, dodecyl, pentadecyl and the like. The term lower alkyl refers to an alkyl group of one to six carbon atoms.

The term alkoxy, as used herein, refers to a straight or branched chain saturated aliphatic hydrocarbonoxy group of one to fifteen carbon atoms, e.g., methoxy, ethoxy, n-propoxy, i-propoxy, n-butoxy, i-butoxy, n-heptyloxy, n-dodecyloxy, Z-methyloctyloxy, and the like.

The term cycloalkyl, as used herein, refers to a monovalent cycloalkyl moiety of four to eight carbon atoms, i.e. cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl.

The term aryl, as used herein, refers to a monovalent aromatic hydrocarbon group containing from six to fourteen carbon atoms such as phenyl, tolyl, xylyl, mesityl, naphthyl, ehtylphenyl, t-butylphenyl, isopropylphenyl, chlorophenyl, and methoxyphenol.

The term aralkyl, as used herein, refers to a monovalent hydrocarbon group containing from seven to carbon atoms in which a hydrogen atom of an alkyl group having a chain length of one to six carbon atoms is substituted by an aryl group, such as benzyl, phenethyl, methylbenzyl, naphthylmethyl and naphthylethyl.

The terms aryloxy" and aralkyloxy, as used herein, refer to the groups aryl-O- andaralkyl-O- where aryl and aralkyl are as defined above.

The term halogen, as used herein, refers to fluorine, chlorine and bromine.

The esters of the present invention are useful for the control of mites and ticks which are ectoparasitic on animals and birds. The esters can be applied in either solution or in powder (dust) form in a conventional manner.

The following examples are. provided to illustrate the syntheses of the compounds of the present invention and the practice of the present invention. Temperature is reported in degrees Centigrade.

EXAMPLE 1 To a mixture of 3.46 g. of anhydrous sodium hydrosulfide and 14 ml. dimethylformamide is added with cooling 4.0 g. of cyclopropanemethyl chloride. After standing two hours at room temperature, water and ether are added, the aqueous phase separated and extracted with ether, and the combined organic phases washed with brine, dried over calcium sulfate, filtered and distilled to yield cyclopropanemethyl mercaptan, boiling at 97-98 at 1 atm.

EXAMPLE 2 To a solution of 3.05 g. of trans-cinnamic acid in dry benzene is added 5 ml. of oxalyl chloride. The reaction mixture is stirred at room temperature, under nitrogen, for two hours. Solvent is removed in vacuo and replaced. by fresh dry benzene and 3.9 ml. of cyclopropanemethyl alcohol is added. The reaction mixture is stirred overnight at room temperature, under nitrogen. The reaction is worked up by washing with water and brine, drying over calcium sulfate and evaporating under reduced pressure and fractionally distilling to yield the cyclopropanemetyl ester of trans-cinnamic acid, (cyclopropanemethyl trans-cinnamate) b.p. 100 (bath) at .1 mm.

EXAMPLE 3 To a solution of 3.5 g. of p-methylcinnamic acid and 2.4 ml. of thionyl chloride in dry ether is added 0.5 ml. dry diemthylfonnamide. The reaction mixture is stirred at room temperature for six days. The top layer of the biphasic mixture is decanted and the volatile material is removed by evaporation under reduced pressure. The residue is taken up in dry ether and 2.34 g. of cyclopropanemethyl alcohol is added followed, at 0, by 5.2 ml. of dry pyridine. The reaction mixture is stirred at room temperature for one day. The reaction is worked up by addition of water, ether and pentane, separating the organic layer, and then washing with sulfuric acid, potassium carbonate, water and brine. The solution is dried over calcium sulfate and evaporated under re duced pressure and fractionally distilled to yield the cyclopropanemethyl p-methylcinnamate, b,p. (bath) 95-l00 (0.0L mm).

Following the procedure of this example, the acids of Column I are converted to the corresponding acid chlo- 4 ride and then reacted with cyclopropylmethyl alcohol to yield the esters of Column II.

p-chlorocinnamic acid p-methoxycinnamic acid p-benzylcinnamic acid p-benzyloxycinnamic acid 4-(benzyloxy)-3,S-dimethoxycinnamic acid m-bromocinnamic acid p-bromocinnamic acid p-butoxycinnamic acid 4-butoxy-3-fluorocinnamic acid 3-chloro-4-methoxycinnamic acid 2-chloro-5-methylcinnamic acid p-(dodecyloxy)cinnamic acid p-ethoxycinnamic acid p-ethylcinnamic acid m-fluorocinnamic acid p-(isohexyloxy)cinnamic acid p-isopropoxycinnamic acid p-isopropylcinnamic acid o-methoxycinnamic acid p-(p-methylphenethyl)cinnamic acid p-(octyloxy)cinnamic acid p-phenoxycinnamic acid p-phenylcinnamic acid 2,4,5-trimethoxycinnamic acid p-octylcinnamic acid S-(p-chlorophenyl)valeric acid 5-(phenyl)valeric acid 5-p-octylphenyl)valeric acid 5-(p-octyloxyphenyl)valeric acid S-(p-methoxyphenyl)-valeric acid S-(p-methylphenyl)-valeric acid Z-naphthylacetic acid cyclopropanemethyl p-chlorocinnamate cyclopropanemethyl p-methoxycinnamate cyclopropanemethyl p-benzylcinnamate cyclopropanemethyl p-benzyloxycinnamate cyclopropanemethyl 4-( b enzyloxy )-3 ,5 -dimethoxycinnamate cyclopropanemethyl m-bromocinnamate cyclopropanemethyl p-bromocinnamate cyclopropanemethyl p-butoxycinnamate cyclopropanemethyl 4-butoxy-3-fluorocinnamate cyclopropanemethyl 3-chloro-4-methoxycinnamate cyclopropanemethyl 2-chloro-5-methylcinnamate cyclopropanemethyl p-(dodecyloxy)cinnamate cyclopropanemethyl p-ethoxycinnate cyclopropanemethyl p-ethylcinnamate. cyclopropanemethyl m-fluorocinnamate cyclopropanemethyl p-( isohexyloxy )cinnamate cyclopropanemethyl p-isopropoxycinnamate cyclopropanemethyl p-isopropylcinnamate cyclopropanemethyl o-methoxycinnamate cyclopropanemethyl p-(p-methylphenethyl)cinnamate cyclopropanemethyl p-(octyloxy)cinnamate cyclopropanemethyl p-phenoxycinnamate cyclopropanemethyl p-phenylcinnamate cyclopropanemethyl 2,4,5-trimethoxycinnamate cyclopropanemethyl p-octylcinnamate cyclopropanemethyl 5-(p-chlorophenyl)valerate cyclopropanemethyl 5-(phenyl)valerate cyclopropanemethyl 5-(p-octylphenyl)valerate cyclopropanemethyl 5-( p-octyloxyphenyl )valerate cyclopropanemethyl S-(p-methoxyphenyl)-valerate cyclopropanemethyl 5-( p-methylphenyl )-valerate cyclopropanemethyl 2-naphthylacetate EXAMPLE 4 To a solution of 17.08 ml. of n-butyl lithium in hexane, under nitrogen, at 5 is added dropwise 1.965 g. of cyclopropylmethyl alcohol. The reaction mixture is stirred for one-half hour at room temperature and then the hexane is evaporated under reduced pressure. Dry tetrahydrofuran is added to the residue, forming an orange-yellow slurry. To this slurry is slowly added, as a solution in tetrahydrofuran, 2.36 g. of octyl p-(octyloxy)-cinnamate [prepared from p-hydroxycinnamic acid and excess octyliodide in the presence of potas sium carbonate and diemthylformamide]. The reaction mixture is stirred at room temperature overnight. The resultant brown solution is worked up by adding water and extracting with ether, washing the ether layer with water and brine, drying over calcium sulfate, filtering, and evaporating under reduced pressure. The resultant product is separated by preparative thin-layer chromatography to yield 0.65 g. of cyclopropanemethyl p-(octyloxy) cinnamate, m.p. 3637.5.

EXAMPLE 5 To a solution of .035 g. of p-octylbenzoic acid and 0.035 ml. dimethylformamide in dry ether is added, at 8, 0.161 ml. of thionyl chloride. The reaction mixture is stirred for two hours at room temperature and then cooled to 10C. To this stirred mixture, under nitrogen, is then added 0.140 g. of cyclopropylmethyl alcohol. The addition of 0.18 ml. of pyridine yields an immediate white precipitate. After stirring overnight at room temperature, the reaction is worked up by adding water and ether, acidifying, extracting with ether, adding sodium bicarbonate until slightly basic, washing with water, copper sulfate, water and brine, drying over calcium sulfate, filtering, drying and then separating the product, cyclopropylmethy] ester of 4-octylbenzoate, b.p. (bath) 113 (0.03 mm).

Using the above procedure, the esters of Column IV are prepared from the acids of Column III.

III

benzoic acid 2,4-dichlorobenzoic acid 4-phenylbenzoic acid 4-methoxybenzoic acid 4-ethylbenzoic acid l-naphthoic acid Z-naphthylacetic acid 4(benzyloxy)benzoic acid Z-naphthoic acid 4-( S-methoxynaphthyl butyric acid 4-octyloxybenzoic acid 4-phenoxybenzoic acid 4-methylbenzoic acid 4-chlorobenzoic acid 3-(2,4-dichlorophenyl)propionic acid 7(3,5-dimethoxyphenyl)heptanoic acid 8-(4-octylphenyl)octanoic acid cyclopropanemethyl benzoate cyclopropanemethyl 2,4-dichlorobenzoate cyclopropanemethyl 4-phenylbenzoate 6 cyclopropanemethyl 4-methoxybenzoate cyclopropanemethyl 4-ethylbenzoate cyclopropanemethyl l-naphthoate cyclopropanemethyl Z-naphthylacetate cyclopropanemethyl 4(benzyloxy)benzoate cyclopropanemethyl Z-naphthoate cyclopropanemethyl 4-(5-methoxynaphthyl )butyrate cyclopropanemethyl 4-octyloxybenzoate cyclopropanemethyl 4-phenoxybenzoate cyclopropanemethyl 4-methylbenzoate cyclopropanemethyl 4-chlorobenzoate cyclopropanemethyl 3-( 2,4-dichlorophenyl )propionate cyclopropanemethyl tanoate cyclopropanemethyl 8-(4-octylphenyl)octanoate Following the procedure of Example 3, the acids of Column V are converted to the corresponding acid chloride and esterfied with cyclopropanemethyl alcohol to yield the compounds of Column VI.

5-phenyl-2,4-pentadienoic acid 5-(4-biphenylyl)-2,4-pentadienoic acid 5-(o-methoxyphenyl)-2,4-pentadienoic acid S-(p-methoxyphenyl)-2,4-pentadienoic acid 5-( l-naphthyl)-2,4-pentadienoic acid S-(m-chlorophenyl)-2,4-pentadienoic acid 5-( 3 ,4-dichlorophenyl )-2,4-pentadienoic acid 5-( 2,6-dichlorophenyl )-2,4-pentadienoic acid 5-(p-bromophenyl)-2,4-pentadienoic acid 5-(pchlorophenyl)-2,4-pentadienoic acid 5-(Z-naphthyl)-2,4-pentadienoic acid 5-(3,4-dimethoxyphenyl)-2,4-pentadienoic acid VI cyclopropanemethyl 5-phenyl-2,4-pentadienoate 7-( 3 ,S-dimethoxyphenyl )hepcyclopropanemethyl 5-(4-biphenylyl)-2,4-pentadienoate cyclopropanemethyl 5-(o-methoxyphenyl)-2,4-pentadienoate cyclopropanemethyl 5-(p-methoxyphenyl)-2,4-pentadienoate cyclopropanemethyl 5-( l-naphthyl )-2,4-pentadienoate cyclopropanemethyl S-(m-chlorophenyl)-2,4-pentadienoate cyclopropanemethyl 5-( 3 ,4-dichlorophenyl )-2 ,4-

pentadienoate cyclopropanemethyl 5-(2,6-dichlorophenyl)-2,4-

pentadienoate cyclopropanemethyl S-(p-bromophenyl)-2,4-pentadienoate cyclopropanemethyl 5-(p-chlorophenyl)-2,4-pentadienoate cyclopropanemethyl 5-(Z-naphthyl)-2,4-pentadienoate cyclopropanemethyl 5-( 3,4-dimethoxyphenyl )-2,4- pentadienoate Those compounds where R is cycloalkyl are prepared by treating the appropriate cycloalkane carboxaldehyde with an equimolar amount of triethyl phosphonoacetate in dimethyl formamide solution with a slight molar excess of sodium hydroxide. The reaction is carried out under nitrogen and at from 20 to reflux. The resultant ethyl ester of the 3-cycloalkane acrylic acid can be directly treated with about a 4.5 molar excess of lithium cyclopropanemethyl alcoholate in tetrahydrofuan to yield the desired cyclopropanemethyl ester. It is, however, preferred to treat the ethyl cycloalkaneacrylate with aqueous sodium hydroxide and methanol to obtain the free acid which is then esterified according to the procedure of Example 3. Using this preferred method, the acids of Column VII are converted to the esters of Column VIII.

VII

3-cyclohexaneacrylic acid 3cyclobutaneacrylic acid 3-cyclopentaneacrylic acid 3-cycloheptaneacrylic acid 3-cyclooctaneacrylic acid 3-(4-methoxycyclohexane)acrylic acid 3-( 4-chlorocyclohexane )acrylic acid I 5 3-(4-octyloxycyclohexane)acrylic acid 3-(4-methylcyclohexane )acrylic acid VIII cyclopropanemethyl 3-cyclohexaneacrylate cyclopropanemethyl 3-cyclobutaneacrylate cyclopropanemethyl 3-cyclopentaeneacrylate cyclopropanemethyl 3-cycloheptaneacrylate cyclopropanemethyl 3-cyclooctaneacrylate Thioesters are prepared by treating a solution of the corresponding acid in benzene with oxalyl chloride, heating for one to eight hours and then removing the benzene solvent. To this concentrate is added a molar excess of the cyclopropanemethyl mercaptan, prepared in Example 1, in ether, followed by the addition at 0 of pyridine. The reaction mixture is stirred at room temperature and then refluxed for from one to five days and the product separated by pouring the mixture into water, adding ether, separating the organic phase, washing with aqueous sodium bicarbonate and brine, drying over calcium sulfate and removing the solvent.

In the above manner, the acids of Column I and of 45 Example 2 are converted to the thio esters of Column IX.

2-chloro-5-methylcinna- S-(cyclopropanemethyl) m-fluorocinnamate S-(cyclopropanemethyl) p-(isohexyloxy)cinnamate S-(cyclopropanemethyl) p-isopropoxycinnamate S-(cyclopropanemethyl) p-isopropyylcinnamate S-(cyclopropanemethyl) o-methoxycinnamate S-(cyclopropanemethyl) p-(p-methylphenethyl)cinnamate S-(cyclopropanemethyl) p-(octyloxy)cinnamate S-( cyclopropanemethyl) p-phenoxycinnamate S-(cyclopropanemethyl) p-phenylcinnamate S-( cyclopropanemethyl) 2,4,5 -trimethoxycinnamate S-cyclopropanemethylcinnamate The mite control agents of the present invention can be used alone in an inert agriculturally acceptable carrier substance for the control of mites (Arachnids) or can be used in mixture with insecticides and/or juvenile hormone analogs known in the art to provide a broader spectrum of activity.

The effectiveness of the compounds of the present invention is demonstrated below.

Adults (Tetranychus urticae) are allowed to oviposit for twenty-four hours on castor bean leaf discs (1 cm.) on moist cottonwool.

After twenty-four hours, the adults are removed and the leaf discs are then dipped in acetone solutions of cyclopropanemethyl p-chlorocinnamate and of cyclopropanemethyl p-octylbenzoate at 0.1 percent.

After submersion for one second, the solvent on the leaf discs is allowed to dry and the leaf discs are then glued to a plastic petri dish to prevent crumpling.

Six days later (when all the eggs on untreated discs have emerged), the number of unhatched eggs is calculated as a percentage of the total number originally present, corrected for any spontaneous non-emergence observed in control discs treated only with solvent (Abbott correction).

Both cyclopropanemethyl p-chlorocinnamate and cyclopropanemethyl p-octylbenzoate at the above concentration prevent the hatching of 100 percent of the eggs.

A wettable powder suitable for field application after dilution can be formulated by blending and then airmilling a mixture of 20 to 30 percent of an ester of this invention, 60 to percent of a solid carrier such as Attaclay X-250, l to 3 percent of an anionic surfactant, such as Igepon T-77, and 3 to 5 percent of a dispersing agent such as Marasperse N-22.

The wettable powder is applied, after dilution with water, using ultra-low volume sprayers. Dilutions containing the ester within a concentration range of about 0.01 to 10 percent are generally employed.

We claim as our invention:

1. A compound of formula (A) wherein n is one or two and R is phenyl or naphthyl, each optionally substituted by one or more of the groups, alkyl of one to ten carbon atoms, phenyl,

9 10 4, A compound of h f l 5. The compound, cyclopropanemethyl p-chlorocinnamate.

6. The compound, cyclopropanemethyl p-methylcinnamate. ll 7. The compound, cyclopropanemethyl l-naphtho- Y-cH-cH-c-o-cH ate.

8. The compound, cyclopropanemethyl 4-phenylbenzoate.

9. The compound, cyclopropanemethyl 4-octylben- 1O zoate.

wherein Y is methyl, octyl, phenyl, benzyl or chloro. 

1. A COMPOUND OF FORMULA (A)
 2. A compound according to claim 1 wherein R is phenyl or naphthyl, each optionally substituted by alkyl of one to ten carbon atoms, chlorine or bromine.
 3. The compound, cyclopropanemethyl cinnamate.
 4. A compound of the formula
 5. The compound, cyclopropanemethyl p-chlorocinnamate.
 6. The compound, cyclopropanemethyl p-methylcinnamate.
 7. THE COMPOUND, CYCLOPROPANEMETHYL 1-NAPHTHOATE.
 8. THE COMPOUND, CYCLOPROPHANEMETHYL 4-PHENYLBENZOATE.
 9. THE COMPOUND, CYCLOPROPANEMETHYL 4-OCTYLBENZOATE. 